JNCASR Scientists develop potential drug candidate for Alzheimer’s treatment



A group of scientists from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) have designed a set of novel small molecules that could disrupt the mechanism through which neurons become dysfunctional in Alzheimer’s disease (AD). 

The molecule could reduce the toxicity of Amyloid Beta (Aβ) toxicity and be a potential drug candidate to halt or cure the leading cause of dementia (70-80%) worldwide. 

Key Details

•  In Alzheimer’s disease , usually abnormal levels of naturally forming protein accumulate to form plaques that collect between neurons and disrupt cell function.

•  This is caused due to production and deposition of the amyloid peptide (Aβ), which collects in the central nervous system.

•  However, detailed studies have established the TGR63 molecule as a potential candidate to rescue neuronal cells from amyloid toxicity. 

•  The molecule is found to reduce amyloid burden in the cortex and hippocampus, a complex part embedded deep into the temporal lobe, thereby reversing cognitive decline. 

•  The research was published recently in the journal Advanced Therapeutics.

Research results 

•  When mice with Alzheimer’s disease were treated with TGR63, their brain showed a significant reduction of amyloid deposits. 

•  The mice also showed a reduction in memory impairment, learning deficiency and cognitive decline.

•  These attributes validate the potential of TGR63 as a promising drug candidate for the treatment of Alzheimer’s Disease. 

Alzheimer’s Treatment

There is no particular drug that can directly act on the disease mechanisms of Alzheimer’s disease to cure or halt it. The current available treatments only provide temporary relief. 

The disease severely affects the patients, caregivers and families and hence is a major societal and economic burden globally. 




UPPSC ACF RFO 2019 Mains Result Released @uppsc.up.nic.in, Download State/Upper Subordinate Service PCS ACF, RFO Result 2021 Here



UPPSC ACF RFO 2019 Mains Result: Uttar Pradesh Public Service Commission (UPPSC) has released Combined State/Upper Subordinate Service PCS ACF, RFO Mains Result on its website. Download State/Upper Subordinate Service PCS ACF, RFO Result 2021 Here

UPPSC ACF RFO 2019 Mains Result: Uttar Pradesh Public Service Commission (UPPSC) has released Combined State/Upper Subordinate Service PCS ACF, RFO Mains Result on its website. All such candidates who appeared in the UPPSC ACF RFO 2019 Mains can download their result through the official website of UPPSC.i.e.uppsc.up.nic.in.

UPPSC ACF RFO 2019 Mains Exam was conducted from 15 October to 29 October 2020 at Prayagraj Exam Centre. In which, 197 candidates appeared. The result of the selected candidates has now uploaded to the official website of UPPSC. The candidates can download UPPSC ACF RFO 2019 Mains Result by following the easy steps given below.

  1. Visit on the official website.i.e.uppsc.up.nic.in.
  2. Click on LIST OF CANDIDATES QUALIFIED FOR THE INTERVIEW IN ASSISTANT CONSERVATOR OF FOREST/RANGE FOREST OFFICER EXAM-2019 flashing on the homepage.
  3. It will redirect you to a PDF.
  4. Candidates can search their roll numbers in the PDF and save the result for future reference.

Download UPPSC ACF RFO 2019 Mains Exam Result

The result of the above candidates is provisional. The shortlisted candidates are eligible for Interview. The schedule for the interview will be shortly uploaded to the official website. All candidates are advised to keep checking on the official website for the latest updates.

This recruitment is being done to recruit 200 vacancies through Assistant Forest Conservator ACF and Rural Forest Officer RFO Recruitment 2019. The candidates will be appointed in different departments on the basis of their performance in written test and interview. The candidates can download UPPSC ACF RFO 2019 Mains Exam Result by clicking on the above link.

Latest Government Jobs:

RBI Assistant Manager Recruitment 2021 Notification Released @rbi.org.in for 29 Vacancies, Online Applications to Start from 27 February

RBI Recruitment 2021 Notification for Various Non CSG Posts,Online Application Started @rbi.org.in, Exam on 10 April, Salary upto 77208/-




Apply for 96 Senior Resident and Junior Resident Posts



GSVM Medical College Kanpur have invited applications for the Senior Resident and Junior Resident posts. Eligible and interested persons can apply for GSVM Medical College Kanpur Recruitment Notification 2021 through the prescribed application format on or before 08 & 10 March 2021.

GSVM Medical College Kanpur Recruitment 2021: GSVM Medical College Kanpur have invited applications for the Senior Resident and Junior Resident posts. Eligible and interested persons can apply for GSVM Medical College Kanpur Recruitment Notification 2021 through the prescribed application format on or before 08 & 10 March 2021.

Applications are invited from GSVM Medical College Uttar Pradesh (UP) in prescribed form through online mode only for various Assistant posts. The direct link for the online application official portal is available at GSVM Medical College, Kanpur website scr.indianrailways.gov.in. GSVM Medical College, Kanpur has already published the employment notice on 24 February 2021 regarding 96 posts. As per the GSVM Medical College, Kanpur post notification, these vacancies are assigned to Senior and Junior Resident post wise vacancy details are given below. Persons who are seeking central and state government jobs in GSVM Medical College, Kanpur can make the GSVM Medical College, Kanpur Registration by using GSVM Medical College, Kanpur login on or before 08 & 10 March 2021.

Important Date:

  • Application Form Closing Date: 08 & 10 March 2021

GSVM Medical College Kanpur Senior Resident and Junior Resident Vacancy Details

  • Senior Resident: 15 Posts
  • Junior Resident: 81 Posts

Eligibility Senior Resident and Junior Resident Job

MBBS Degree passes in recognized university/institute. Age Limit: 18 years to 54 years.

Salary:

  • Senior Resident: Rs. 15600-Rs. 39100 Pay Grade Rs. 6600.
  • Junior Resident: Rs. 66000

Selection Process: Written Test, Interview and document verification will be conducted for selection of suitable persons for GSVM Medical College Kanpur Vacancy.

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How to Apply

Eligible and interested persons can apply for GSVM Medical College Kanpur Recruitment Notification 2021 through the prescribed application format on or before 08 & 10 March 2021.

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US Senate confirms Linda Thomas-Greenfield’s nomination as US ambassador to UN



The US Senate on February 23, 2021 confirmed Linda Thomas-Greenfield as US ambassador to the United Nations. Greenfield’s name was nominated for the post by US President Joe Biden.

The Senate voted 78-20 to confirm Thomas-Greenfield for the Cabinet-level position. Greenfield is the eighth confirmed member of President Joe Biden’s Cabinet.

Linda Thomas-Greenfield is a US diplomat with vast experience in Africa. She is a three-decade veteran of the US State Department. 

Key Highlights 

•  Linda Thomas-Greenfield is exceptionally qualified and in her new role, she will have to work to rebuild America’s reputation and reasserting the first instrument of American power and diplomacy. 

•  Her appointment comes as the Biden administration is taking steps to reassert the US position within the United Nations by reversing policy decisions taken by former President Trump’s administration, which left the US isolated globally. 

•  Her appointment also comes at a time when the US is rallying allies to push back against the military coup in Myanmar and amid the Biden administration’s renewed push for diplomacy to resolve the Yemeni civil war. 

•  However, Greenfield’s biggest task will be asserting US leadership and uniting allies to confront China’s influence and ambitions at the global body.

About Linda Thomas-Greenfield

•  Linda Thomas-Greenfield is a retired foreign service veteran, who had resigned during the Trump administration.

•  She will be the third African-American and the second African American woman to hold the post of UN ambassador to the UN. 

•  Greenfield is expected to work with international partners to confront their collective challenges head-on and play an active role in ensuring that the United Nations evolves with the demands of the era. 

Following her confirmation to the post, Thomas-Greenfield made it clear that there would be a change under Biden to re-engage internationally and promote American values.

She stressed that US leadership must be rooted in the country’s core values — “support for democracy, respect for universal human rights and the promotion of peace and security.” 

She added saying that effective diplomacy means developing “robust relationships,” finding common ground and managing differences, and “doing genuine, old-fashioned, people-to-people diplomacy.”




Apply for 296 Home Guard Volunteer Posts



Home Guard and Civil Defence Organization Recruitment 2021: Home Guard and Civil Defence Organization have invited applications for the Home Guard Volunteer posts. Eligible and interested persons can apply for Home Guard and Civil Defence Organization Recruitment Notification 2021 through the prescribed application format on or before 31 March 2021.

Applications forms in prescribed format are invited from eligible persons for enrolling 296 (Two hundred Ninety Six) Home Guard Volunteers in the Home Guard and Civil Defence Organization initially for a period of three (03) years only. The persons Who Have Already Served as Home Guard Volunteers Earlier Need Not Apply Again.

Important Date:

  • Application Form Closing Date: 31 March 2021

Home Guard and Civil Defence Organization Home Guard Volunteer Vacancy Details

  • Home Guard Volunteer: 296 Posts

Eligibility Home Guard Volunteer Job

Class 8th (VIII) Passed. Age Limit: Not less than 20 years and not more than 50 years as on the last date of receipt of applications forms i.e. 31 March 2021.

Selection Procedure

  1. i) Physical Test (Qualifying Run), ii) Height, iii) Written Test, iv) Oral Test, v) Diploma in Trade: Auto Electrician, Electrician, Moto Mechanic, Carpentry, Welding, Blacksmith etc. from recognized Institute.

2. The written examination of 35 marks will be held in the following subjects:

(i) General Knowledge: 1 5 marks   

(ii) General English:10 marks   

(iii) Mathematics: 10 marks   

  1. The minimum passing marks in the written examination will be 40% i.e. 14 marks. In case candidate scores less than 40% marks, he/she will be declared as Failed in the Written Examination. Only successful persons in the written examination will be called for oral interview.

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How to Apply

Eligible and interested persons can apply for Home Guard and Civil Defence Organization Recruitment Notification 2021 through the prescribed application format on or before 31 March 2021. The persons possessing the above mentioned qualifications as on 31 March 2021 and possessing 15 years Residence Certificate (valid) issued by the Competent Authority may submit their application forms to the Commandant Gen. Home Guards and Dir., Civil Defence, Panaji-Goa in the prescribed Application Form.

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Israel doles out small batches of vaccine as diplomatic perks



“Over the past month, a limited quantity of unused vaccines was accumulated; therefore, it has been decided to assist Palestinian Authority medical teams and several of the countries that contacted Israel with a symbolic quantity of vaccines,” the statement said.

The announcement did not say how many doses would be donated or name the recipient countries. Israeli media, citing diplomatic sources, said they included Honduras and Guatemala, which have opened embassies in Jerusalem. Also on the list reportedly were Hungary, which recently opened a trade mission in the city, and the Czech Republic, which has said it intends to open a diplomatic office of some kind there soon. Jerusalem is claimed as a capital by both Israel and the Palestinians.

Israel’s Ministry of Foreign Affairs declined to comment.

Using vaccine as an apparent diplomatic reward was criticized by some public health experts and by Netanyahu’s opponents.

“The fact that Netanyahu trades in vaccines funded by Israeli taxpayers without discussion and accountability shows that he is running a kingdom and not a country,” said Defense Minister Benny Gantz, who will oppose Netanyahu in elections next month.

Vaccine was also apparently a bargaining chip in a recent prisoner swap between Israel and Syria. In exchange for the return of an Israeli woman who illegally crossed the Syrian border, Israel reportedly agreed to pay for thousands of doses of the Russian Sputnik vaccine to be delivered to Damascus.

Israel has yet to publicly confirm that arrangement. A public health adviser to the government said Wednesday that the plans were still being finalized. The symbolic donation announced Tuesday is apparently unrelated to that larger effort.